Jens Lykkesfeldt Selected Research

Ascorbic Acid (Vitamin C)

3/2022	Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity.
1/2022	Lower Vitamin C Levels Are Associated With Less Improvement in Negative Symptoms in Initially Antipsychotic-Naïve Patients With First-Episode Psychosis.
12/2021	Vitamin C Deficiency May Delay Diet-Induced NASH Regression in the Guinea Pig.
1/2021	The role of vitamin C in epigenetic cancer therapy.
1/2021	Collagen remodelling and plasma ascorbic acid levels in patients suspected of inherited bleeding disorders harbouring germline variants in collagen-related genes.
1/2021	Discrepancies in global vitamin C recommendations: a review of RDA criteria and underlying health perspectives.
1/2020	On the effect of vitamin C intake on human health: How to (mis)interprete the clinical evidence.
10/2019	Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes.
1/2018	Long term Westernized diet leads to region-specific changes in brain signaling mechanisms.
7/2017	Vitamin C Deficiency Reduces Muscarinic Receptor Coronary Artery Vasoconstriction and Plasma Tetrahydrobiopterin Concentration in Guinea Pigs.

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Jens Lykkesfeldt Research Topics

Disease

26	Inflammation (Inflammations) 12/2021 - 12/2002
15	Ascorbic Acid Deficiency (Vitamin C Deficiency) 12/2021 - 05/2002
13	Non-alcoholic Fatty Liver Disease 03/2022 - 01/2016
12	Cardiovascular Diseases (Cardiovascular Disease) 03/2022 - 06/2009
12	Dyslipidemias (Dyslipidemia) 03/2022 - 12/2014
11	Body Weight (Weight, Body) 03/2022 - 01/2013
11	Atherosclerosis 01/2021 - 10/2004
8	Infections 03/2015 - 07/2002
6	Obesity 03/2022 - 09/2014
5	Alcoholic Fatty Liver 03/2022 - 01/2016
5	Fibrosis (Cirrhosis) 04/2021 - 06/2019
5	Neoplasms (Cancer) 01/2021 - 01/2012
4	Scurvy (Scorbutus) 01/2020 - 01/2009
4	Cystic Fibrosis (Mucoviscidosis) 01/2020 - 08/2014
4	Lung Diseases (Lung Disease) 01/2020 - 08/2014
4	Insulin Resistance 02/2016 - 05/2011
3	Schizophrenia (Dementia Praecox) 01/2022 - 10/2013
3	Disease Progression 12/2021 - 09/2018
3	Glucose Intolerance 07/2021 - 01/2013
3	Type 2 Diabetes Mellitus (MODY) 01/2020 - 09/2014
3	Endotoxemia 01/2020 - 11/2013
2	Overweight 03/2022 - 03/2015
2	Chronic Disease (Chronic Diseases) 03/2022 - 01/2012
2	AIDS-Related Complex (ARC) 03/2022 - 01/2020
2	Weight Gain 07/2021 - 01/2013
2	Heart Failure 01/2021 - 09/2020
2	Weight Loss (Weight Reduction) 01/2021 - 12/2018
2	Acute-Phase Reaction 01/2021 - 01/2020
2	Atherosclerotic Plaque (Atheroma) 01/2021 - 01/2016
2	Hyperglycemia 01/2021 - 01/2020
2	Liver Diseases (Liver Disease) 11/2020 - 01/2020
2	Malnutrition (Nutritional Deficiencies) 01/2020 - 12/2007
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2020 - 01/2018
2	Hyperemia 01/2020 - 03/2015
2	Hypoglycemia (Reactive Hypoglycemia) 11/2019 - 01/2016
2	Persistent Infection 10/2019 - 08/2014
2	Ischemia 01/2019 - 05/2005
2	Pain (Aches) 06/2018 - 07/2013
2	Atrophy 01/2018 - 07/2017

Drug/Important Bio-Agent (IBA)

32	Ascorbic Acid (Vitamin C)FDA LinkGeneric 03/2022 - 05/2002
15	AntioxidantsIBA 12/2021 - 07/2002
14	CholesterolIBA 02/2021 - 01/2011
13	LipidsIBA 04/2021 - 01/2011
11	Biomarkers (Surrogate Marker)IBA 01/2020 - 05/2008
9	Insulin (Novolin)FDA Link 01/2021 - 09/2014
6	Malondialdehyde (Propanedial)IBA 01/2021 - 05/2005
6	Interleukin-6 (Interleukin 6)IBA 01/2020 - 05/2005
6	MelatoninIBA 10/2019 - 05/2008
5	Vitamin E FDA LinkGeneric 12/2021 - 12/2002
5	C-Reactive ProteinIBA 01/2020 - 06/2003
5	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2016 - 06/2005
5	Glucose (Dextrose)FDA LinkGeneric 02/2016 - 09/2014
4	EnzymesIBA 04/2021 - 11/2014
4	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 10/2013
4	Glutathione (Reduced Glutathione)IBA 01/2020 - 12/2007
4	Tocopherols (Tocopherol)IBA 01/2020 - 12/2007
4	LipopolysaccharidesIBA 01/2020 - 11/2013
4	Anti-Bacterial Agents (Antibiotics)IBA 10/2019 - 06/2005
4	Dehydroascorbic AcidIBA 11/2014 - 07/2011
4	Proteins (Proteins, Gene)FDA Link 12/2007 - 07/2002
3	ApolipoproteinsIBA 01/2021 - 01/2016
3	Apolipoproteins E (ApoE)IBA 01/2021 - 01/2016
3	Particulate MatterIBA 01/2021 - 06/2011
3	Streptozocin (Streptozotocin)FDA Link 01/2021 - 09/2015
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 01/2014
3	EndotoxinsIBA 01/2020 - 02/2014
3	Biological ProductsIBA 10/2019 - 01/2012
3	sapropterin (tetrahydrobiopterin)FDA Link 06/2018 - 03/2015
3	CytokinesIBA 06/2018 - 11/2013
3	oxidized low density lipoproteinIBA 01/2018 - 09/2015
3	Interleukin-10 (Interleukin 10)IBA 11/2014 - 11/2013
3	InterleukinsIBA 11/2014 - 11/2013
2	Pharmaceutical PreparationsIBA 03/2022 - 09/2015
2	Antipsychotic Agents (Antipsychotics)IBA 01/2022 - 04/2015
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 12/2021 - 01/2018
2	FructoseIBA 02/2021 - 01/2018
2	coenzyme Q10 (CoQ10)IBA 01/2021 - 09/2020
2	Triglycerides (Triacylglycerol)IBA 01/2021 - 01/2018
2	5-hydroxymethylcytosineIBA 01/2021 - 10/2019
2	5-Methylcytosine (5 Methylcytosine)IBA 01/2021 - 10/2019
2	MethyltransferasesIBA 01/2021 - 10/2019
2	Liraglutide FDA Link 01/2021 - 12/2018
2	Serum Amyloid A Protein (Serum Amyloid A)IBA 01/2021 - 01/2020
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 03/2015
2	Blood Glucose (Blood Sugar)IBA 01/2020 - 01/2017
2	Hemoglobins (Hemoglobin)IBA 01/2020 - 05/2005
2	HaptoglobinsIBA 01/2020 - 01/2018
2	Arginine (L-Arginine)FDA Link 01/2020 - 04/2015
2	Antigen-Antibody Complex (Immune Complex)IBA 01/2020 - 12/2019
2	Complement System Proteins (Complement)IBA 01/2020 - 12/2019
2	Alanine Transaminase (SGPT)IBA 11/2019 - 01/2018
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 11/2019 - 01/2018
2	Neurotransmitter Agents (Neurotransmitter)IBA 06/2018 - 01/2018
2	Dietary Fats (Dietary Fat)IBA 01/2018 - 01/2011
2	Sucrose (Saccharose)IBA 01/2018 - 01/2016

Therapy/Procedure

5	Therapeutics 01/2021 - 12/2004
3	Drug Therapy (Chemotherapy) 11/2020 - 06/2017
2	Fat-Restricted Diet (Diet, Fat Restricted) 12/2021 - 01/2018
2	Glycemic Control 01/2020 - 01/2016
2	Oral Administration 10/2019 - 07/2004